6,528 research outputs found
Cross-institution online problem based learning in Chinese Medicine Education
New education technology drives the pedagogical changes nowadays. Teaching and learning collaborations can now be extended beyond institutional boundaries. This study reports a new attempt of cross-institution collaboration in co-teaching a Chinese Medicine course. A Cross-institution Online Problem-based Learning (COPBL) is designed and implemented by the University of Hong Kong (HKU) and Chengdu University of Traditional Chinese Medicine (CDUTCM). There are 25 students from HKU and 24 students from CDUTCM who have participated in the COPBL. It is a supplementary component to courses and a seven-step approach has been adopted. Students work individually and collaboratively with floating-facilitators. The classes are blended with face-to-face and online components. As an initial step to understand the effectiveness of COPBL, this study specifically focuses on students’ use of the discussion forum, which is a key online component in COPBL. There are 91.8% of students who have viewed the discussion forum in total, 839 of view counts in all discussion forums. There are 63 replies recorded in all of the discussion forums. The replies could be identified into following categories, comments (33%), comments and questions (27%), responses (37%), and others (3%).This study has demonstrated that problem-based learning can be conducted in a blended form with traditional classroom teaching methods and well-designed online components. The COPBL offers new possibilities in redesigning pedagogy with new education technology. It could bring our education into a new era surrounded with new learning experiences.postprin
MYOD-1 in normal colonic mucosa : role as a putative biomarker?
Background
DNA methylation of promoter-associated CpG islands of certain genes may play a role in the development of colorectal cancer. The MYOD-1 gene which is a muscle differentiation gene has been showed to be significantly methylated in colorectal cancer which, is an age related event. However the role of this gene in the colonic mucosa is not understood and whether methylation occurs in subjects without colon cancer. In this study, we have determined the frequency of methylation of the MYOD-1 gene in normal colonic mucosa and investigated to see if this is associated with established colorectal cancer risk factors primarily ageing.
Results
We analysed colonic mucosal biopsies in 218 normal individuals and demonstrated that in most individuals promoter hypermethylation was not quantified for MYOD-1. However, promoter hypermethylation increased significantly with age (p < 0.001 using regression analysis) and this was gender independent. We also showed that gene promoter methylation increased positively with an increase in waist to hip (WHR) ratio – the latter is also a known risk factor for colon cancer development.
Conclusions
Our study suggests that promoter gene hypermethylation of the MYOD-1 gene increases significantly with age in normal individuals and thus may offer potential as a putative biomarker for colorectal cancer
Measurement of sulfur L2,3 and carbon K edge XANES in a polythiophene film using a high harmonic supercontinuum
We use a high harmonic generated supercontinuum in the soft X-ray region to measure X-ray absorption near edge structure (XANES) spectra in polythiophene (poly(3-hexylthiophene)) films at multiple absorption edges. A few-cycle carrier-envelope phase-stable laser pulse centered at 1800 nm was used to generate a stable soft X-ray supercontinuum, with amplitude gating limiting the generated pulse duration to a single optical half-cycle. We report a quantitative transmission measurement of the sulfur L2,3 edge over the range 160-200 eV and the carbon K edge from 280 to 330 eV. These spectra show all the features previously reported in the XANES spectra of polythiophene, but for the first time they are measured with a source that has an approximately 1 fs pulse duration. This study opens the door to measurements that can fully time-resolve the photoexcited electronic dynamics in these systems
Quantum states made to measure
Recent progress in manipulating quantum states of light and matter brings
quantum-enhanced measurements closer to prospective applications. The current
challenge is to make quantum metrologic strategies robust against
imperfections.Comment: 4 pages, 3 figures, Commentary for Nature Photonic
Hardness, yield strength, and plastic flow in thin film metallic-glass
2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Optical Trapping of an Ion
For several decades, ions have been trapped by radio frequency (RF) and
neutral particles by optical fields. We implement the experimental
proof-of-principle for trapping an ion in an optical dipole trap. While
loading, initialization and final detection are performed in a RF trap, in
between, this RF trap is completely disabled and substituted by the optical
trap. The measured lifetime of milliseconds allows for hundreds of oscillations
within the optical potential. It is mainly limited by heating due to photon
scattering. In future experiments the lifetime may be increased by further
detuning the laser and cooling the ion. We demonstrate the prerequisite to
merge both trapping techniques in hybrid setups to the point of trapping ions
and atoms in the same optical potential.Comment: 5 pages, 3 figure
Activated Magnetospheres of Magnetars
Like the solar corona, the external magnetic field of magnetars is twisted by
surface motions of the star. The twist energy is dissipated over time. We
discuss the theory of this activity and its observational status. (1) Theory
predicts that the magnetosphere tends to untwist in a peculiar way: a bundle of
electric currents (the "j-bundle") is formed with a sharp boundary, which
shrinks toward the magnetic dipole axis. Recent observations of shrinking hot
spots on magnetars are consistent with this behavior. (2) Continual discharge
fills the j-bundle with electron-positron plasma, maintaining a nonthermal
corona around the neutron star. The corona outside a few stellar radii strongly
interacts with the stellar radiation and forms a "radiatively locked" outflow
with a high e+- multiplicity. The locked plasma annihilates near the apexes of
the closed magnetic field lines. (3) New radiative-transfer simulations suggest
a simple mechanism that shapes the observed X-ray spectrum from 0.1 keV to 1
MeV: part of the thermal X-rays emitted by the neutron star are reflected from
the outer corona and then upscattered by the inner relativistic outflow in the
j-bundle, producing a beam of hard X-rays.Comment: 23 pages, 7 figures; review chapter in the proceedings of ICREA
Workshop on the High-Energy Emission from Pulsars and Their Systems, Sant
Cugat, Spain, April 201
Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels
PMCID: PMC3480949This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Impact of Age and Body Site on Adult Female Skin Surface pH
Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo. Methods: Time domain dual lifetime referencing with luminescent sensor foils was used for pH(SS) measurements. pH(SS) was measured on the forehead, the temple, and the volar forearm of adult females (n = 97, 52.87 +/- 18.58 years, 20-97 years). Every single measurement contained 2,500 pH values due to the luminescence imaging technique used. Results: pH(SS) slightly increases with age on all three investigated body sites. There are no significant differences in pH(SS) between the three investigated body sites. Conclusion: Adult pH(SS) on the forehead, the temple and the volar forearm increases slightly with age. This knowledge is crucial for adapting medical skin care products. Copyright (C) 2012 S. Karger AG, Base
Graphene Bilayer Structures with Superfluid Magnetoexcitons
We study superfluid behavior of a gas of spatially indirect magnetoexcitons
with reference to a system of two graphene layers embedded in a multilayer
dielectric structure. The system is considered as an alternative of a double
quantum well in a GaAs haterostructure. We determine a range of parameters
(interlayer distance, dielectric constant, magnetic field and gate voltage)
where magnetoexciton superfluidity can be achieved. Temperature of superfluid
transition is computed. A reduction of critical parameters caused by impurities
is evaluated and critical impurity concentration is determined
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